Frk Gene Summary [Mouse]
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; cell surface receptor protein tyrosine kinase signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frk |
| Official Name | fyn-related kinase [Source:MGI Symbol;Acc:MGI:103265] |
| Ensembl ID | ENSMUSG00000019779 |
| Bio databases IDs | |
| Aliases | fyn-related kinase |
| Synonyms | BSK, BSK/IYK, fyn-related kinase, fyn-related Src family tyrosine kinase, GTK, PTK5, RAK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Src homology 2 (SH2) domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Frk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- hepatocellular carcinoma
- tumorigenesis
- metastatic gastrointestinal stromal tumor
- colorectal cancer
- metastatic progressive colorectal cancer
- advanced colon cancer
- gastroesophageal junction adenocarcinoma
- gastroesophageal junction carcinoma
- undifferentiated gastric carcinoma
role in cell
- expression in
- proliferation
- migration
- morphology
- invasion
- outgrowth
- colony formation by
- epithelial-mesenchymal transition
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- secretory granule lumen
- azurophil granule lumen
- Cytoplasm
- Extracellular Space
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- innate immune response
- cell differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- specific granule lumen
- cytosol
- extracellular region
- azurophil granule lumen
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- receptor binding