CAMSAP2 Gene Summary [Human]
Enables microtubule minus-end binding activity. Involved in several processes, including axon development; regulation of dendrite development; and regulation of organelle organization. Located in cytosol and microtubule end. Colocalizes with Golgi apparatus; centrosome; and microtubule minus-end. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CAMSAP2 |
| Official Name | calmodulin regulated spectrin associated protein family member 2 [Source:HGNC Symbol;Acc:HGNC:29188] |
| Ensembl ID | ENSG00000118200 |
| Bio databases IDs | |
| Aliases | calmodulin regulated spectrin associated protein family member 2 |
| Synonyms | 1600013L13Rik, 4930541M15Rik, calmodulin regulated spectrin associated protein family member 2, calmodulin regulated spectrin-associated protein family, member 2, CAMSAP1L1, mKIAA1078, RGD1310950 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAMSAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Spectrin-binding region of Ca2+-Calmodulin
- calponin homology (CH) domain superfamily
- Microtubule-binding calmodulin-regulated spectrin-associated
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- growth failure
- colorectal cancer
- organismal death
- insulin-dependent diabetes mellitus
- epilepsy
- metastasis
- myocardial infarction
role in cell
- expression in
- migration
- growth
- phosphorylation in
- abnormal morphology
- organization
- development
- invasion by
- polymerization
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular tracklike structure
- microtubule cytoskeleton
- basal bodies
- centrosome
- Golgi Apparatus
- cytosol
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAMSAP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendrite development
- regulation of organelle organization
- regulation of microtubule polymerization
- negative regulation of microtubule depolymerization
- microtubule cytoskeleton organization
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- spectrin binding
- microtubule minus-end binding