POLE3 Gene Summary [Human]
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Details
| Type | Processed Transcript |
| Official Symbol | POLE3 |
| Official Name | DNA polymerase epsilon 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:13546] |
| Ensembl ID | ENSG00000148229 |
| Bio databases IDs | |
| Aliases | DNA polymerase epsilon 3, accessory subunit, histone fold protein CHRAC17, DNA polymerase epsilon p17 subunit, chromatin accessibility complex 17, arsenic transactivated protein, chromatin accessibility complex subunit 2 |
| Synonyms | 1810034K18Rik, CHARAC17, CHRAC17, CHRAC2, DNA polymerase epsilon 3, accessory subunit, DNA polymerase ε 3, accessory subunit, p17, polymerase (DNA directed), epsilon 3 (p17 subunit), polymerase (DNA directed), ε 3 (p17 subunit), YBL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLE3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- histone fold domain (HFD) superfamily
- DNA-directed DNA polymerase
- tail domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the POLE3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- relapsing-remitting multiple sclerosis
- acute myeloid leukemia
- relapsed acute myeloid leukemia
- RUNX1-RUNX1T1 positive acute myeloid leukemia
- diffuse large B-cell lymphoma
- relapsing multiple sclerosis
- B-cell non-Hodgkin lymphoma
- de novo unfavorable cytogenetic risk acute myeloid leukemia
role in cell
- formation in
- formation
- assembly
- sliding
- cohesion in
- remodeling
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLE3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- heterochromatin assembly
- DNA replication
- DNA-dependent DNA replication
- leading strand elongation
- DNA biosynthetic process
- regulation of DNA replication
- response to DNA damage stimulus
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- centromeric heterochromatin
- chromatin accessibility complex
- nucleoplasm
- epsilon DNA polymerase complex
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- DNA-directed DNA polymerase activity
- protein binding
- protein heterodimerization activity