LY9 Gene Summary [Human]
LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | LY9 |
| Official Name | lymphocyte antigen 9 [Source:HGNC Symbol;Acc:HGNC:6730] |
| Ensembl ID | ENSG00000122224 |
| Bio databases IDs | |
| Aliases | lymphocyte antigen 9 |
| Synonyms | CD229, hly9, Lgp100, lymphocyte antigen 9, mLY9, SLAMF3, T100 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LY9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- cytosolic tail domain
- Immunoglobulin V-set domain
- tyrosine-based motif
- Grb2 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- multisystem inflammatory syndrome in children
- diabetic nephropathy
- tauopathy
- amyloidosis
role in cell
- expression in
- proliferation
- production in
- quantity
- survival
- killing
- elimination
- expansion
- number
- lysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LY9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- T-helper 17 cell lineage commitment
- positive regulation of interleukin-17 production
- T cell activation
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane