SLC52A1 Gene Summary [Human]
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | SLC52A1 |
| Official Name | solute carrier family 52 member 1 [Source:HGNC Symbol;Acc:HGNC:30225] |
| Ensembl ID | ENSG00000132517 |
| Bio databases IDs | |
| Aliases | solute carrier family 52 member 1, riboflavin transporter 1 |
| Synonyms | GPCR, GPCR42, GPR172B, hRFT1, huPAR-2, PAR2, RBFVD, RFT1, RFVT1, solute carrier family 52 member 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC52A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- organic anion transporter
- transporter
- Protein of unknown function (DUF1011)
Pathways
Biological processes and signaling networks where the SLC52A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- lung adenocarcinoma formation
- riboflavin deficiency
- lung adenocarcinoma
- maternal riboflavin deficiency
role in cell
- phosphorylation in
- expression in
- proliferation
- transmembrane potential
- activation in
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC52A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- riboflavin transport
- riboflavin metabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- viral receptor activity
- riboflavin transporter activity