TAOK3 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | TAOK3 |
| Official Name | TAO kinase 3 [Source:HGNC Symbol;Acc:HGNC:18133] |
| Ensembl ID | ENSG00000135090 |
| Bio databases IDs | |
| Aliases | TAO kinase 3 |
| Synonyms | 2900006A08Rik, A130052D22, A430105I05Rik, DPK, hKFC-A, JIK, MAP3K18, TAO3, TAO kinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAOK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- transferase
- Protein tyrosine and serine/threonine kinase
- protein kinase inhibitor activity
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the TAOK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- major depression
- neoplasia
- metastasis
- systemic lupus erythematosus
- neuroticism
- diabetic retinopathy
role in cell
- growth
- phosphorylation in
- expression in
- apoptosis
- quantity
- formation
- accumulation in
- number
- growth in
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAOK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- regulation of MAPK cascade
- positive regulation of JUN kinase activity
- neuron projection morphogenesis
- protein autophosphorylation
- negative regulation of JNK cascade
- response to DNA damage stimulus
- protein phosphorylation
- MAPK cascade
- positive regulation of JNK cascade
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transferase activity
- protein serine/threonine kinase activity
- protein kinase inhibitor activity