ARPC5L Gene Summary [Human]
Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARPC5L |
| Official Name | actin related protein 2/3 complex subunit 5 like [Source:HGNC Symbol;Acc:HGNC:23366] |
| Ensembl ID | ENSG00000136950 |
| Bio databases IDs | |
| Aliases | actin related protein 2/3 complex subunit 5 like |
| Synonyms | 2010015J01RIK, actin related protein 2/3 complex subunit 5 like, Actin related protein 2/3 complex, subunit 5-like, ARC16-2, ARP5L, Arpc5l1, Arpc5l2, RGD1560362 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARPC5L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ARP2/3 complex 16 kDa subunit (p16-Arc)
- protein binding
Pathways
Biological processes and signaling networks where the ARPC5L gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- FAK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cilia
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARPC5L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- Arp2/3 complex-mediated actin nucleation
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- Arp2/3 protein complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding