GLIPR1 Gene Summary [Human]
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | GLIPR1 |
| Official Name | GLI pathogenesis related 1 [Source:HGNC Symbol;Acc:HGNC:17001] |
| Ensembl ID | ENSG00000139278 |
| Bio databases IDs | |
| Aliases | GLI pathogenesis related 1 |
| Synonyms | 2410114O14Rik, CRISP7, GLIOMA PATHOGENESIS RELATED, GLI pathogenesis-related 1, GLIPR, LOC120093588, mRTVP-1, RTVP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLIPR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
- signal peptide
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- glioblastoma cancer
- endometrial cancer
- prostate cancer
- androgenic alopecia
- laser induced choroidal neovascularization
- prostatic intraepithelial neoplasia
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- binding in
- cell cycle progression
- degradation in
- transactivation in
- destruction in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- Plasma Membrane
- secretory granule membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLIPR1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding