DNAJA4 Gene Summary [Human]
Enables chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DNAJA4 |
| Official Name | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] |
| Ensembl ID | ENSG00000140403 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member A4 |
| Synonyms | 1110021L12Rik, Dj4, DnaJ heat shock protein family (Hsp40) member A4, Hsj4, mmDjA4, MST104, MSTP104, PRO1472 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger domain of DnaJ and HSP40
- DnaJ domain
- chaperone protein DnaJ
- DnaJ
- DnaJ central domain
- DnaJ molecular chaperone homology domain
- DnaJ C terminal domain
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the DNAJA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- metastasis
- systemic juvenile idiopathic arthritis
- organismal death
- cerebral aneurysm
role in cell
- expression in
- invasion by
- migration
- migration by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to heat
- positive regulation of gene expression
- negative regulation of endothelial cell migration
- protein refolding
- negative regulation of inclusion body assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- chaperone binding
- unfolded protein binding
- Hsp70 protein binding