MYLK3 Gene Summary [Human]
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MYLK3 |
| Official Name | myosin light chain kinase 3 [Source:HGNC Symbol;Acc:HGNC:29826] |
| Ensembl ID | ENSG00000140795 |
| Bio databases IDs | |
| Aliases | myosin light chain kinase 3, MLC kinase |
| Synonyms | caMLCK, cMLCK, D830007F02Rik, LOC633594, LOC676159, MLCK, MLCK2, myosin light chain kinase 3, RGD1305801 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYLK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- myosin light chain kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- amphipathic helix
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- calmodulin regulated protein kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MYLK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac hypertrophy
- fibrosis
- cardiac fibrosis
- ventricular hypertrophy
- congestive heart failure
- streptozotocin-induced diabetic nephropathy
role in cell
- expression in
- assembly
- function
- organization
- abnormal morphology
- contraction
- permeability
- disassembly
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYLK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of sarcomere organization
- regulation of vascular permeability involved in acute inflammatory response
- sarcomere organization
- cellular response to interleukin-1
- cardiac myofibril assembly
- protein phosphorylation
- sarcomerogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- calmodulin-dependent protein kinase activity
- myosin light chain kinase activity