Mylk3 Gene Summary [Mouse]
Enables calcium/calmodulin-dependent protein kinase activity and myosin light chain kinase activity. Involved in protein phosphorylation and sarcomere organization. Located in cytoplasm. Colocalizes with actin cytoskeleton. Is expressed in heart atrium; heart ventricle; inner ear; liver; and tibialis anterior. Orthologous to human MYLK3 (myosin light chain kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mylk3 |
| Official Name | myosin light chain kinase 3 [Source:MGI Symbol;Acc:MGI:2443063] |
| Ensembl ID | ENSMUSG00000031698 |
| Bio databases IDs | |
| Aliases | myosin light chain kinase 3 |
| Synonyms | caMLCK, cMLCK, D830007F02Rik, LOC633594, LOC676159, MLCK, MLCK2, myosin light chain kinase 3, RGD1305801 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mylk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- myosin light chain kinase
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- amphipathic helix
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- calmodulin regulated protein kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mylk3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac hypertrophy
- fibrosis
- cardiac fibrosis
- ventricular hypertrophy
- congestive heart failure
- streptozotocin-induced diabetic nephropathy
role in cell
- expression in
- assembly
- function
- organization
- abnormal morphology
- contraction
- permeability
- disassembly
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mylk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of sarcomere organization
- regulation of vascular permeability involved in acute inflammatory response
- sarcomere organization
- cellular response to interleukin-1
- cardiac myofibril assembly
- protein phosphorylation
- sarcomerogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- calmodulin-dependent protein kinase activity
- myosin light chain kinase activity