CD7 Gene Summary [Human]
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD7 |
| Official Name | CD7 molecule [Source:HGNC Symbol;Acc:HGNC:1695] |
| Ensembl ID | ENSG00000173762 |
| Bio databases IDs | |
| Aliases | CD7 molecule, p41 protein, T-cell antigen CD7, T-cell leukemia antigen |
| Synonyms | CD7 antigen, CD7 molecule, GP40, LEU-9, Tp40, TP41 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypereosinophilia
- diabetic nephropathy
- acute myeloid leukemia with t(8;21)
- insulin-dependent diabetes mellitus
- T acute lymphoblastic leukemia
- psoriasis
- early precursor T-cell acute lymphoblastic leukemia
- mycosis fungoides/sezary syndrome
- T-cell large granular lymphocytic leukemia
- T-cell lymphoblastic lymphoma
role in cell
- cell death
- number
- cell viability
- apoptosis
- quantity
- activation
- redistribution
- cytolysis by
- degranulation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- T cell activation
- transmembrane receptor protein tyrosine kinase signaling pathway
- adaptive immune response
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity