Ei24 Gene Summary [Mouse]
Predicted to enable importin-alpha family protein binding activity. Acts upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ei24 |
| Official Name | etoposide induced 2.4 mRNA [Source:MGI Symbol;Acc:MGI:108090] |
| Ensembl ID | ENSMUSG00000062762 |
| Bio databases IDs | |
| Aliases | etoposide induced 2.4 mRNA |
| Synonyms | EI24 autophagy associated transmembrane protein, EI24, autophagy associated transmembrane protein, EPG4, etoposide induced 2.4 mRNA, PIG8, TP53I8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ei24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBB-like domain
- Etoposide-induced protein 2.4 (EI24)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early-onset breast cancer
- abdominal aortic aneurysm
- tubulo-interstitial fibrosis
- hepatomegaly
- neurological disorder
- demyelination
- mental retardation
role in cell
- activation in
- apoptosis
- hypertrophy
- growth
- binding in
- loss
- cell death
- inactivation in
- autophagy
- vacuolation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ei24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth
- apoptotic process
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding