NMRAL1 Gene Summary [Human]
This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | NMRAL1 |
| Official Name | NmrA like redox sensor 1 [Source:HGNC Symbol;Acc:HGNC:24987] |
| Ensembl ID | ENSG00000153406 |
| Bio databases IDs | |
| Aliases | NmrA like redox sensor 1, short chain dehydrogenase/reductase family 48A, member 1 |
| Synonyms | 1110025F24RIK, HSCARG, LOC100910915, NmrA-like family domain containing 1, NmrA like redox sensor 1, RGD1311451, SDR48A1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NMRAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- protein binding
- identical protein binding
- NmrA-like family
- NAD(P)H-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NMRAL1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding