AK5

AK5 Gene Summary

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
AK5
Official Name
adenylate kinase 5 [Source:HGNC Symbol;Acc:HGNC:365]
Ensembl ID
ENSG00000154027
Bio databases IDs NCBI: 26289 Ensembl: ENSG00000154027
Aliases adenylate kinase 5
Synonyms
adenylate kinase 5,AK6
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase
  • nucleoside diphosphate kinase
  • adenylate kinase
  • NK
  • adenylate kinase, isozyme 1 subfamily
  • UMP-CMP kinase family
  • N-terminal helicase domain of the DEAD-box helicase superfamily
  • DD_R_PKA_DPY30-like
  • AAA domain

Pathways

Biological processes and signaling networks where the AK5 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • CEBPA
  • AK5
  • UGDH
  • HTT
  • STRN4
  • WDTC1
  • YWHAZ
  • DPYSL2
  • TRIM46
  • CPNE6
disease
  • non-small cell lung cancer
  • small vessel disease stroke
  • glioblastoma
  • glioblastoma cancer
  • COVID-19
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • bipolar disorder
  • non-small cell lung carcinoma
  • bipolar I disorder
regulated by
  • EWSR1-FLI1
  • WWTR1
  • MRTFB
  • HTT
  • TEAD3
  • TEAD4
  • TEAD2
  • TEAD1
  • TBX3
  • NTRK1
regulates
  • dADP
  • ADP
  • pyrimidine ribonucleotide
role in cell
  • survival

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • centrosome
  • cytosol
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the AK5 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • pyrimidine ribonucleotide biosynthetic process
  • ADP biosynthetic process
  • dADP biosynthetic process
  • ATP metabolic process
  • nucleoside monophosphate phosphorylation

CELLULAR COMPONENT

Where in the cell the gene product is active
  • cytoplasm
  • centriolar satellite
  • cytosol

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • ATP binding
  • adenylate kinase activity
  • nucleoside diphosphate kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.