This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
kinase
nucleoside diphosphate kinase
adenylate kinase
NK
adenylate kinase, isozyme 1 subfamily
UMP-CMP kinase family
N-terminal helicase domain of the DEAD-box helicase superfamily
DD_R_PKA_DPY30-like
AAA domain
Pathways
Biological processes and signaling networks where the AK5 gene plays a role, providing insight into its function and relevance in health or disease.
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
CEBPA
AK5
UGDH
HTT
STRN4
WDTC1
YWHAZ
DPYSL2
TRIM46
CPNE6
disease
non-small cell lung cancer
small vessel disease stroke
glioblastoma
glioblastoma cancer
COVID-19
lung adenocarcinoma
lung adenocarcinoma formation
bipolar disorder
non-small cell lung carcinoma
bipolar I disorder
regulated by
EWSR1-FLI1
WWTR1
MRTFB
HTT
TEAD3
TEAD4
TEAD2
TEAD1
TBX3
NTRK1
regulates
dADP
ADP
pyrimidine ribonucleotide
role in cell
survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
Cytoplasm
centrosome
cytosol
plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AK5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
pyrimidine ribonucleotide biosynthetic process
ADP biosynthetic process
dADP biosynthetic process
ATP metabolic process
nucleoside monophosphate phosphorylation
CELLULAR COMPONENT
Where in the cell the gene product is active
cytoplasm
centriolar satellite
cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
ATP binding
adenylate kinase activity
nucleoside diphosphate kinase activity
Gene-Specific Assays for Results You Can Trust
Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.