Ak5 Gene Summary [Mouse]
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in ATP metabolic process and nucleoside monophosphate phosphorylation. Predicted to be located in centriolar satellite. Predicted to be active in cytosol. Is expressed in alimentary system; cranium; nervous system; and urinary system. Orthologous to human AK5 (adenylate kinase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak5 |
| Official Name | adenylate kinase 5 [Source:MGI Symbol;Acc:MGI:2677491] |
| Ensembl ID | ENSMUSG00000039058 |
| Bio databases IDs | |
| Aliases | adenylate kinase 5 |
| Synonyms | adenylate kinase 5, AK6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ak5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- adenylate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DD_R_PKA_DPY30-like
- AAA domain
Pathways
Biological processes and signaling networks where the Ak5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- small vessel disease stroke
- glioblastoma
- glioblastoma cancer
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- bipolar disorder
- non-small cell lung carcinoma
- bipolar I disorder
regulates
- dADP
- ADP
- pyrimidine ribonucleotide
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ak5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyrimidine ribonucleotide biosynthetic process
- ADP biosynthetic process
- dADP biosynthetic process
- ATP metabolic process
- nucleoside monophosphate phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- centriolar satellite
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- adenylate kinase activity
- nucleoside diphosphate kinase activity