USP28 Gene Summary [Human]
The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | USP28 |
| Official Name | ubiquitin specific peptidase 28 [Source:HGNC Symbol;Acc:HGNC:12625] |
| Ensembl ID | ENSG00000048028 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 28 |
| Synonyms | 9830148O20RIK, mKIAA1515, ubiquitin specific peptidase 28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- peptidase
- USP25_USP28_C-like
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the USP28 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- glioblastoma cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- non-small cell lung cancer
- prostate cancer
- hepatocellular carcinoma
- liver cancer
- organismal death
role in cell
- activation in
- cell viability
- apoptosis
- expression in
- growth
- proliferation
- differentiation
- Gap 0-Gap 1 phase
- senescence
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- protein deubiquitination
- DNA damage checkpoint
- DNA repair
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- regulation of protein stability
- cellular response to UV
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- response to DNA damage stimulus
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding