TNFRSF14 Gene Summary [Human]
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF14 |
| Official Name | TNF receptor superfamily member 14 [Source:HGNC Symbol;Acc:HGNC:11912] |
| Ensembl ID | ENSG00000157873 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 14, herpesvirus entry mediator |
| Synonyms | ATAR, CD270, HVEA, HVEM, LIGHTR, LOC100131742, MGC108903, TNF receptor superfamily member 14, Tnfrs14, TR2, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator), tumour necrosis factor receptor superfamily member 14, tumour necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- ubiquitin protein ligase binding
- extracellular domain
- cytokine binding
- cytoplasmic domain
- tumor necrosis factor receptor
- ectodomain
- TNFR/NGFR cysteine-rich region
- receptor agonist activity
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the TNFRSF14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- non-Hodgkin disease
- lymphomagenesis
- hematologic cancer
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- malignant hematopoietic neoplasm
- experimental autoimmune encephalomyelitis
- atopic dermatitis
role in cell
- expression in
- activation in
- apoptosis
- cell death
- proliferation
- chemotaxis
- S phase
- viral entry
- entrance
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- defense response to Gram-negative bacterium
- T cell costimulation
- adaptive immune response
- cell surface receptor signaling pathway
- negative regulation of alpha-beta T cell proliferation
- positive regulation of T cell migration
- positive regulation of cytokine production involved in immune response
- tumor necrosis factor-mediated signaling pathway
- immune response
- innate immune response
- positive regulation of peptidyl-tyrosine phosphorylation
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- tumor necrosis factor-activated receptor activity
- viral receptor activity
- cytokine binding