ORAI2
ORAI2 Gene Summary
Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in growth cone. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ORAI2 |
| Official Name | ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667] |
| Ensembl ID | ENSG00000160991 |
| Bio databases IDs | |
| Aliases | ORAI calcium release-activated calcium modulator 2, CAP-binding protein complex interacting protein 2 |
| Synonyms | A730041O15Rik,C7orf19,CBCIP2,MEM142B,ORAI calcium release-activated calcium modulator 2,RGD1310213,TMEM142B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- store-operated calcium channel
- protein binding
- ion channel
- Mediator of CRAC channel activity
Pathways
Biological processes and signaling networks where the ORAI2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SETDB1
- VIRMA
- COPS6
- UNC119
- GDF9
- STIM1
- TRPC3
- STING1
- CRACR2A
- MED31
disease
- metastasis
- neoplasia
- insomnia
- organismal death
- skin infection by Staphylococcus aureus
regulated by
- ERG
- ATP2A2
- CD28
- TP53
- CD3 (complex)
- POU4F2
- LRRK2
- SND1
- STIM1
regulates
- Ca2+
- PI3K (family)
- AKT
- reactive oxygen species
- leukotriene B4
- IL13
- IL5
- calcium release-activated calcium channel
- RAF1
- NFATC2
role in cell
- production in
- migration
- degranulation
- phosphorylation in
- function
- engulfment by
- motility
- degranulation in
- store-operated calcium influx in
- engulfment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ORAI2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- store-operated calcium entry
- calcium ion transmembrane transport
CELLULAR COMPONENT
Where in the cell the gene product is active
- growth cone
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- store-operated calcium channel activity
- protein binding