BCL6B Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of inflammatory response; and type 2 immune response. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BCL6B |
| Official Name | BCL6B transcription repressor [Source:HGNC Symbol;Acc:HGNC:1002] |
| Ensembl ID | ENSG00000161940 |
| Bio databases IDs | |
| Aliases | BCL6B transcription repressor |
| Synonyms | BAZF, B cell CLL/lymphoma 6, member B, BCL6B transcription repressor, BCL6B, transcription repressor, RGD1563179, ZBTB28, zinc finger protein 62, ZNF62 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCL6B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- BTB_POZ
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
role in cell
- expression in
- apoptosis
- upregulation in
- cell viability
- quantity
- proliferation
- colony formation
- degradation in
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BCL6B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cytokine production
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription