SKA3 Gene Summary [Human]
This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | SKA3 |
| Official Name | spindle and kinetochore associated complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:20262] |
| Ensembl ID | ENSG00000165480 |
| Bio databases IDs | |
| Aliases | spindle and kinetochore associated complex subunit 3 |
| Synonyms | C13orf3, F630043A04Rik, IMAGE:3604003, RAMA1, RGD1307201, spindle and kinetochore associated complex subunit 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SKA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- breast carcinoma
- organismal death
- prostatic adenocarcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometrial adenocarcinoma
- prostate cancer
- metastasis
role in cell
- migration
- invasion by
- expression in
- proliferation
- phosphorylation in
- cell death
- polyubiquitination in
- survival
- chromosomal congression
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- spindle fibers
- mitotic spindle
- meiotic spindles
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SKA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic sister chromatid segregation
- chromosome segregation
- regulation of microtubule polymerization or depolymerization
- mitotic cell cycle
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- centrosome
- mitotic spindle
- cytosol
- kinetochore
- condensed chromosome outer kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding