MAP3K2 Gene Summary [Human]
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K2 |
| Official Name | mitogen-activated protein kinase kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6854] |
| Ensembl ID | ENSG00000169967 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 2, MAP/ERK kinase kinase 2 |
| Synonyms | 9630061B06RIK, AI585793, LOC100506904, M3K2, MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- MAP kinase kinase kinase
- proline tyrosine motif
- PB1
- Phox and Bem1 domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- active site
- basic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP3K2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- Caveolar-mediated Endocytosis Signaling
- CD27 Signaling in Lymphocytes
- ERK5 Signaling
- G-Protein Coupled Receptor Signaling
- Gap Junction Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- Nur77 Signaling in T Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic juvenile idiopathic arthritis
role in cell
- apoptosis
- phosphorylation in
- expression in
- binding in
- activation in
- degradation in
- proliferation
- adhesion
- signaling
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to mechanical stimulus
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein binding
- metal ion binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity