DHX36 Gene Summary [Human]
This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DHX36 |
| Official Name | DEAH-box helicase 36 [Source:HGNC Symbol;Acc:HGNC:14410] |
| Ensembl ID | ENSG00000174953 |
| Bio databases IDs | |
| Aliases | DEAH-box helicase 36, RNA helicase associated with AU-rich element |
| Synonyms | 2810407E23Rik, AI452301, DDX36, DEAH-box helicase 36, G4R1, mKIAA1488, MLEL1, RHAU |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHX36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- ATP binding
- enzyme
- Helicase conserved C-terminal domain
- RNA helicase
- DNA helicase
- double-stranded RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DUF1605 domain
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- nucleic acid binding
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- histone deacetylase binding
- protein binding
- DNA dependent ATPase
- magnesium ion binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- AAA domain
- helicase C-terminal domain
- Helicase associated domain (HA2) Add an annotation
- mRNA 3' UTR binding
- single-stranded DNA binding
- mRNA 5' UTR binding
- double-stranded DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- lung cancer
- colon cancer
- liver cancer
- metabolic syndrome X
- progressive dilated cardiomyopathy
- retinopathy
role in cell
- translation in
- production in
- binding in
- differentiation
- ossification by
- response by
- cell proliferation
- replication in
- maintenance
- translocation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- nuclear speckles
- stress granule
- telomeres
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHX36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- positive regulation of transcription initiation from RNA polymerase II promoter
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of mRNA stability
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of interferon-alpha production
- cellular response to heat
- positive regulation of myeloid dendritic cell cytokine production
- ossification
- response to exogenous dsRNA
- DNA duplex unwinding
- cellular response to UV
- defense response to virus
- negative regulation of translation
- positive regulation of telomere maintenance
- positive regulation of dendritic spine morphogenesis
- spermatogenesis
- regulation of embryonic development
- regulation of transcription from RNA polymerase III promoter
- positive regulation of cardioblast differentiation
- positive regulation of cytoplasmic translation
- innate immune response
- positive regulation of gene expression
- cell differentiation
- RNA secondary structure unwinding
- positive regulation of mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- nuclear speck
- perikaryon
- intracellular
- nucleoplasm
- dendrite
- nucleus
- chromosome, telomeric region
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA-dependent ATPase activity
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- G-quadruplex RNA binding
- single-stranded DNA binding
- mRNA 3'-UTR binding
- magnesium ion binding
- ATP binding
- DNA helicase activity
- protein binding
- RNA binding
- RNA helicase activity
- mRNA 5'-UTR binding
- mRNA 3'-UTR AU-rich region binding
- telomeric RNA binding
- G-quadruplex DNA binding
- double-stranded RNA binding
- pre-miRNA binding