HSF1 Gene Summary [Human]
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | HSF1 |
| Official Name | heat shock transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:5224] |
| Ensembl ID | ENSG00000185122 |
| Bio databases IDs | |
| Aliases | heat shock transcription factor 1 |
| Synonyms | Chx1, heat shock factor 1, heat shock transcription factor 1, Hsf, HSTF, HSTF 1, LOC642255 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- heat shock protein binding
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- chromatin binding
- coiled-coil domain
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- protein binding
- Vertebrate heat shock transcription factor
- sequence-specific DNA binding
- DNA binding
- HSF-type DNA-binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- single-stranded DNA binding
- double-stranded DNA binding
- transcription factor activity
- protein heterodimerization
Pathways
Biological processes and signaling networks where the HSF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- advanced cancer
- cancer
- neoplasia
- T acute lymphoblastic leukemia
- hepatic steatosis
- nonalcoholic steatohepatitis
- hepatic fibrosis
- growth failure
- alcoholic steatohepatitis
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- binding
- activation in
- activity
- cell death
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- ribonucleoprotein granule
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- spindle pole
- pronucleus
- PML nuclear bodies
- kinetochores
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of double-strand break repair via nonhomologous end joining
- regulation of cellular response to heat
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- cellular response to copper ion
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- cellular response to estradiol stimulus
- cellular response to heat
- positive regulation of macrophage differentiation
- cellular response to cadmium ion
- negative regulation of protein complex assembly
- cellular response to unfolded protein
- cellular response to hydrogen peroxide
- response to testosterone stimulus
- mRNA transport
- macromolecular complex assembly
- positive regulation of inclusion body assembly
- response to nutrient
- mRNA processing
- defense response
- negative regulation of inclusion body assembly
- positive regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- cellular response to gamma radiation
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- cellular response to xenobiotic stimulus
- response to activity
- negative regulation of cardiac muscle cell apoptotic process
- cellular response to potassium ion
Cellular Component
Where in the cell the gene product is active
- PML body
- kinetochore
- chromatin
- nucleoplasm
- nuclear stress granule
- nucleus
- heterochromatin
- centrosome
- euchromatin
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- chromatin DNA binding
- protein kinase binding
- identical protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- Hsp90 protein binding