TRIM69 Gene Summary [Human]
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM69 |
| Official Name | tripartite motif containing 69 [Source:HGNC Symbol;Acc:HGNC:17857] |
| Ensembl ID | ENSG00000185880 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 69 |
| Synonyms | 4921519C19Rik, HSD-34, RNF36, Trif, Trimless, tripartite motif-containing 69 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM69 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- RING-type zinc-finger
- STAT_CCD
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Crohn disease
- multisystem inflammatory syndrome in children
- preeclampsia
- infection by HIV-2
- infection by HIV-1
- infection by Simian immunodeficiency virus - mac
- infection by severe acute respiratory syndrome coronavirus 2
- infection by vesicular stomatitis virus
role in cell
- expression in
- accumulation
- accumulation in
- cell viability
- phosphorylation in
- formation
- invasion by
- migration
- binding in
- anoikis resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- microtubules
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM69 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- protein localization to centrosome
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nuclear speck
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding