VEGFC Gene Summary [Human]
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | VEGFC |
| Official Name | vascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682] |
| Ensembl ID | ENSG00000150630 |
| Bio databases IDs | |
| Aliases | vascular endothelial growth factor C, vascular endothelial growth factor-related protein |
| Synonyms | AW228853, Flt4-L, Flt4 ligand, LMPH1D, LMPHM4, vascular endothelial growth factor C, VRP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VEGFC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- core domain, structural
- VEGF homology domain
- PDGF
- chemoattractant
- signal peptide
- protein binding
- vascular endothelial growth factor receptor binding
- cleavage site
- growth factor
- KDR binding domain
Pathways
Biological processes and signaling networks where the VEGFC gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Bladder Cancer Signaling
- Clathrin-mediated Endocytosis Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17 Signaling
- IL-8 Signaling
- ILK Signaling
- mTOR Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Tissue Factor in Cancer
- TR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- advanced cancer
- cancer
- anemia
- metastatic colorectal cancer
- neoplasia
- colorectal cancer
- hyperplasia
- endometriosis
- head and neck squamous cell carcinoma
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- formation
- formation in
- apoptosis
- differentiation
- survival
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VEGFC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- positive regulation of cell proliferation
- sprouting angiogenesis
- response to xenobiotic stimulus
- positive regulation of angiogenesis
- negative regulation of osteoblast differentiation
- positive regulation of protein autophosphorylation
- response to hypoxia
- positive regulation of cell division
- regulation of vascular endothelial growth factor receptor signaling pathway
- morphogenesis of embryonic epithelium
- positive regulation of protein secretion
- induction of positive chemotaxis
- signal transduction
- positive regulation of glial cell proliferation
- vascular endothelial growth factor signaling pathway
- negative regulation of blood pressure
- positive regulation of neuroblast proliferation
- positive regulation of mast cell chemotaxis
- positive regulation of blood vessel endothelial cell migration
- organ morphogenesis
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of protein phosphorylation
- substrate-dependent cell migration
- glial cell proliferation
- positive regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- vascular endothelial growth factor receptor 3 binding
- chemoattractant activity