Plxnb3 Gene Summary [Mouse]
Enables Rho GDP-dissociation inhibitor binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of GTPase activity; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in cell surface. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in nervous system. Orthologous to human PLXNB3 (plexin B3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Plxnb3 |
| Official Name | plexin B3 [Source:MGI Symbol;Acc:MGI:2154240] |
| Ensembl ID | ENSMUSG00000031385 |
| Bio databases IDs | |
| Aliases | plexin B3 |
| Synonyms | KIAA1206, PLEXB3, plexin B3, PLEXR, PLXN6, RGD1560615 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxnb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- cell adhesion molecule binding
- protein domain specific binding
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- TIG domain found in plexin
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- PDZ binding motif
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Plxnb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxnb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of GTPase activity
- negative regulation of lamellipodium assembly
- positive chemotaxis
- negative regulation of cell adhesion
- nervous system development
- homophilic cell adhesion
- cell chemotaxis
- positive regulation of axonogenesis
- regulation of GTPase activity
- positive regulation of neuron projection development
- positive regulation of endothelial cell proliferation
- negative regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- Rho GDP-dissociation inhibitor binding
- semaphorin receptor activity