AKT1S1 Gene Summary [Human]
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | AKT1S1 |
| Official Name | AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426] |
| Ensembl ID | ENSG00000204673 |
| Bio databases IDs | |
| Aliases | AKT1 substrate 1, proline-rich Akt substrate, 40 kDa |
| Synonyms | 1110012J22RIK, AI430011, AKT1 substrate 1, Lobe, Lobel, PRAS, PRAS40, Proline-rich AKT substrate |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKT1S1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase inhibitor
- protein kinase inhibitor activity
- Proline-rich AKT1 substrate 1
- protein binding
- TOS domain
Pathways
Biological processes and signaling networks where the AKT1S1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- AMPK Signaling
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- HER-2 Signaling in Breast Cancer
- IL-15 Signaling
- IL-4 Signaling
- mTOR Signaling
- Polyamine Regulation in Colon Cancer
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- estrogen receptor positive HER2 negative PIK3CA mutation positive breast cancer
- pancreatic endocrine tumor
- pancreatic neoplasia
- gout
- melanoma
- melanoma cancer
- ischemic injury
role in cell
- expression in
- activation in
- binding in
- differentiation
- autophagy in
- apoptosis
- number
- invasion by
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKT1S1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nerve growth factor receptor signaling pathway
- negative regulation of cell size
- regulation of apoptotic process
- regulation of neuron apoptotic process
- negative regulation of TOR signaling cascade
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- TORC1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase inhibitor activity
- protein binding
- protein kinase inhibitor activity