IGHG3 Gene Summary [Human]
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in retina homeostasis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGHG3 |
| Official Name | immunoglobulin heavy constant gamma 3 (G3m marker) [Source:HGNC Symbol;Acc:HGNC:5527] |
| Ensembl ID | ENSG00000211897 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant gamma 3 (G3m marker) |
| Synonyms | IgG3, IGH3, IG HEAVY CONSTANT gamma3, immunoglobulin heavy constant gamma 3 (G3m marker), immunoglobulin heavy constant γ 3 (G3m marker) |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGHG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH3 domain (from immunoglobulin)
- hinge domain
- heavy chain domain, constant
- Fc domain
Pathways
Biological processes and signaling networks where the IGHG3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lepromatous leprosy
- pancreatic epithelial cancer
- idiopathic membranous nephropathy
- pancreatic adenocarcinoma
- complete testicular feminization syndrome
- papillary thyroid carcinoma
- papillary thyroid cancer
regulates
- Complement
role in cell
- cell death
- activation
- formation
- lysis
- respiratory burst
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGHG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, classical pathway
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- immunoglobulin complex, circulating
- extracellular region
- plasma membrane
- IgG immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- antigen binding
- immunoglobulin receptor binding