APOL6 Gene Summary [Human]
This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | APOL6 |
| Official Name | apolipoprotein L6 [Source:HGNC Symbol;Acc:HGNC:14870] |
| Ensembl ID | ENSG00000221963 |
| Bio databases IDs | |
| Aliases | apolipoprotein L6 |
| Synonyms | 2310076O14RIK, apolipoprotein L 6, APOL-VI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOL6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Apolipoprotein L
- transporter
Pathways
Biological processes and signaling networks where the APOL6 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- right colon cancer
- non-insulin-dependent diabetes mellitus
- psoriasis
- insulin resistance
role in cell
- expression in
- formation in
- autophagy by
- apoptosis
- activation in
- accumulation in
- size
- degradation in
- lipolysis in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- lipid droplets
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOL6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- lipoprotein metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipid binding