PARG Gene Summary [Human]
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | PARG |
| Official Name | poly(ADP-ribose) glycohydrolase [Source:HGNC Symbol;Acc:HGNC:8605] |
| Ensembl ID | ENSG00000227345 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) glycohydrolase |
| Synonyms | AI413217, PARG99, poly (ADP-ribose) glycohydrolase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- poly(ADp-ribose) glycohydrolase
- Poly (ADP-ribose) glycohydrolase (PARG)
- chromatin binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- liver neoplasia
- epithelial neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- streptozotocin-induced diabetes
role in cell
- expression in
- apoptosis
- formation in
- cell death
- proliferation
- accumulation in
- formation
- quantity
- activation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- mitochondrial matrix
- nucleoplasm
- nuclear bodies
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- regulation of DNA repair
- nucleotide-sugar metabolic process
- base-excision repair, gap-filling
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- mitochondrial matrix
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- poly(ADP-ribose) glycohydrolase activity