NSUN6 Gene Summary [Human]
Enables tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NSUN6 |
| Official Name | NOP2/Sun RNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:23529] |
| Ensembl ID | ENSG00000241058 |
| Bio databases IDs | |
| Aliases | NOP2/Sun RNA methyltransferase 6 |
| Synonyms | 4933403D21Rik, 4933414E04Rik, ARL5B-AS1, LOC102724059, MRT82, NOL1/NOP2/Sun domain family member 6, NOP2/Sun RNA methyltransferase 6, NOPD1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NSUN6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- PUA RNA binding domain
- tRNA (cytosine-5-)-methyltransferase
- PUA domain
- NOL1/NOP2/sun family putative RNA methylase
- 16S rRNA methyltransferase RsmB/F
- enzyme
- AdoMet_MTases
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- diabetes mellitus
- autosomal recessive intellectual developmental disorder type 82
- schizophrenia
- idiopathic scoliosis
- pervasive developmental disorder
regulated by
- 1-(ethylthio)-4-(2-phenylethyl)-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one
role in cell
- expression in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NSUN6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA methylation
- tRNA methylation
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- tRNA (cytosine-5-)-methyltransferase activity
- tRNA binding