EIF4EBP3
EIF4EBP3 Gene Summary
This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | EIF4EBP3 |
| Official Name | eukaryotic translation initiation factor 4E binding protein 3 [Source:HGNC Symbol;Acc:HGNC:3290] |
| Ensembl ID | ENSG00000243056 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E binding protein 3 |
| Synonyms | 4E-BP3,eukaryotic translation initiation factor 4E binding protein 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
- protein binding
- eIF4E binding domain
Pathways
Biological processes and signaling networks where the EIF4EBP3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- EIF4E
- CAND1
- BAP1
- CDKN1A
- EIF4E2
- RPA2
- KLHL18
- AIRE
- AURKB
- CEP250
disease
- weight gain
regulated by
- Immunoglobulin
- insulin
- MTOR
- NKX2-3
regulates
- NOS2
- TNF
- IL6
- PTGS2
- IL12B
- IRF8
- Cxcl11
- EIF4E
- IFN beta
- CCR7
role in cell
- expression in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EIF4EBP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of translational initiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- eukaryotic translation initiation factor 4F complex
- cytoplasm
- membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- translation repressor activity
- eukaryotic initiation factor 4E binding