FMN1 Gene Summary [Human]
This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | FMN1 |
| Official Name | formin 1 [Source:HGNC Symbol;Acc:HGNC:3768] |
| Ensembl ID | ENSG00000248905 |
| Bio databases IDs | |
| Aliases | formin 1, limb deformity protein |
| Synonyms | BB164513, FMN, formin-1, LD, LOC100506959, LOC100653168, LOC101059984, LOC102551877, RGD1306349, RGD1310100 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FMN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- protein binding
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- colorectal cancer
- oligodactyly
- umbilical hernia
- gastric polyp
- Alzheimer disease
role in cell
- phosphorylation in
- transport
- assembly
- polymerization
- function
- disorganization
- disorganization in
- polymerization in
- downregulation in
- retraction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- sarcomere
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FMN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of focal adhesion assembly
- actin nucleation
- positive regulation of actin filament polymerization
- gene expression
- forelimb morphogenesis
- hindlimb morphogenesis
- skeletal system morphogenesis
- positive regulation of actin nucleation
- ureteric bud invasion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- adherens junction
- cytoplasm
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin binding
- SH3 domain binding
- microtubule binding