Fmn1 Gene Summary [Mouse]
Enables SH3 domain binding activity. Acts upstream of or within several processes, including limb morphogenesis; positive regulation of cellular component organization; and ureteric bud invasion. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb bud. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human FMN1 (formin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Fmn1 |
| Official Name | formin 1 [Source:MGI Symbol;Acc:MGI:101815] |
| Ensembl ID | ENSMUSG00000044042 |
| Bio databases IDs | |
| Aliases | formin 1 |
| Synonyms | BB164513, FMN, formin-1, LD, LOC100506959, LOC100653168, LOC101059984, LOC102551877, RGD1306349, RGD1310100 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- protein binding
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- colorectal cancer
- oligodactyly
- umbilical hernia
- gastric polyp
- Alzheimer disease
role in cell
- phosphorylation in
- transport
- assembly
- polymerization
- function
- disorganization
- disorganization in
- polymerization in
- downregulation in
- retraction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- sarcomere
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of focal adhesion assembly
- actin nucleation
- positive regulation of actin filament polymerization
- gene expression
- forelimb morphogenesis
- hindlimb morphogenesis
- skeletal system morphogenesis
- positive regulation of actin nucleation
- ureteric bud invasion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- adherens junction
- cytoplasm
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin binding
- SH3 domain binding
- microtubule binding