MIR145 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR145 |
| Official Name | microRNA 145 [Source:HGNC Symbol;Acc:HGNC:31532] |
| Ensembl ID | ENSG00000276365 |
| Bio databases IDs | |
| Aliases | microRNA 145 |
| Synonyms | hsa-miR-145, hsa-mir-145sh, microRNA 145, microRNA 145a, Mir145a, MIRN145, miRNA145, mmu-miR-145, mmu-mir-145a, rno-miR-145 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR145 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR145 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- seizures
- neoplasia
- breast cancer
- prostate cancer
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- organismal death
role in cell
- formation in
- migration
- proliferation
- expression in
- apoptosis
- quantity
- growth
- formation
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR145 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- positive regulation of cellular response to hypoxia
- negative regulation of cholesterol efflux
- regulation of phenotypic switching
- regulation of smooth muscle contraction
- negative regulation of epithelial to mesenchymal transition
- negative regulation of cardiac muscle hypertrophy
- positive regulation of macrophage differentiation
- positive regulation of macrophage activation
- negative regulation of smooth muscle cell proliferation
- mRNA cleavage involved in gene silencing by miRNA
- regulation of collagen biosynthetic process
- negative regulation of translation involved in gene silencing by miRNA
- negative regulation of SMAD protein import into nucleus
- gene silencing by miRNA
- negative regulation of inflammatory response
- angiotensin-mediated signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- aorta smooth muscle tissue morphogenesis
- regulation of ERK1 and ERK2 cascade
- positive regulation of cardiac vascular smooth muscle cell differentiation
- mesodermal cell differentiation
- ectodermal cell differentiation
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of interleukin-10 production
- actin cytoskeleton organization
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of fibroblast migration
- negative regulation of cell migration
- vascular smooth muscle cell differentiation
- negative regulation of interleukin-16 production
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding