Ephb3 Gene Summary [Mouse]
Enables axon guidance receptor activity. Involved in several processes, including corpus callosum development; neuron projection development; and tube morphogenesis. Acts upstream of or within central nervous system projection neuron axonogenesis and retinal ganglion cell axon guidance. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human EPHB3 (EPH receptor B3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ephb3 |
| Official Name | Eph receptor B3 [Source:MGI Symbol;Acc:MGI:104770] |
| Ensembl ID | ENSMUSG00000005958 |
| Bio databases IDs | |
| Aliases | Eph receptor B3 |
| Synonyms | Cek10, Efnb3r, EK2, EPH receptor B3, ETK2, HEK2, MDK5, Sek4, TYRO6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ephb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- Tyrosine-protein kinase ephrin type A/B receptor-like
- Protein tyrosine and serine/threonine kinase
- axon guidance receptor
- SAM (Sterile alpha motif )
- ectodomain
- ephrin receptor
- Fibronectin type 3 domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Sterile alpha motif
- transmembrane-ephrin receptor
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Ephb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- cleft palate
- androgenic alopecia
- cleft palate syndrome
- diabetic nephropathy
- hypospadia
- hemangioma
- angiomatosis
- papillary thyroid cancer
- omphalocele
role in cell
- expression in
- growth
- survival
- proliferation
- migration
- number
- activation
- formation
- sorting
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- cell-cell contacts
- cytosol
- postsynaptic membrane
- synaptic vesicles
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ephb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinal ganglion cell axon guidance
- regulation of cell-cell adhesion
- palate development
- protein autophosphorylation
- central nervous system projection neuron axonogenesis
- axon guidance
- digestive tract morphogenesis
- protein phosphorylation
- dendritic spine development
- axonal fasciculation
- thymus development
- dendritic spine morphogenesis
- corpus callosum development
- urogenital system development
- regulation of axonogenesis
- angiogenesis
- regulation of GTPase activity
- ephrin receptor signaling pathway
- substrate adhesion-dependent cell spreading
- positive regulation of synapse assembly
- cell migration
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- axon guidance receptor activity
- ephrin receptor activity
- transmembrane-ephrin receptor activity