Cnga2 Gene Summary [Mouse]
This gene encodes a transmembrane protein that is the main subunit of the nucleotide-gated olfactory ion channel, which plays a key role in transducing chemosensory signal resulting from hydrogen sulphide exposure. Signaling pathways mediated by this gene operate in the cilia of type B cells. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, Aug 2022]
Details
| Type | Protein Coding |
| Official Symbol | Cnga2 |
| Official Name | cyclic nucleotide gated channel alpha 2 [Source:MGI Symbol;Acc:MGI:108040] |
| Ensembl ID | ENSMUSG00000005864 |
| Bio databases IDs | |
| Aliases | cyclic nucleotide gated channel alpha 2 |
| Synonyms | CNCA, CNCA1, Cncg4, Cng, CNG2, CNG channel 2, Cyclic nucleotide gated channel 2, cyclic nucleotide gated channel alpha 2, cyclic nucleotide gated channel subunit alpha 2, cyclic nucleotide gated channel subunit α 2, cyclic nucleotide gated channel α 2, LOC100911965, OCNC1, OCNCa, OCNCALPHA, OLFCH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnga2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclic nucleotide-binding domain
- C-terminal leucine zipper domain of cyclic nucleotide-gated channels
- Ion transport protein
- binding protein
- intracellular cGMP activated cation channel
- intracellular cAMP activated cation channel
- identical protein binding
- ion channel
- 3',5'-cGMP binding
- Cyclic nucleotide-monophosphate binding domain
- CAP_ED
Pathways
Biological processes and signaling networks where the Cnga2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- anosmia
role in cell
- expression in
- depolarization
- development
- function
- long-term potentiation
- influx in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent-insoluble fractions
- cilia
- cell surface
- cellular membrane
- olfactory cilia
- Golgi membrane
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnga2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- sodium ion transport
- sensory perception of smell
- calcium ion transport
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- intracellular cyclic nucleotide activated cation channel complex
- Golgi-associated vesicle membrane
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- calcium channel activity
- intracellular cAMP activated cation channel activity
- cAMP binding
- intracellular cGMP activated cation channel activity
- cGMP binding