CNGA2 Gene Summary [Human]
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | CNGA2 |
| Official Name | cyclic nucleotide gated channel subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:2149] |
| Ensembl ID | ENSG00000183862 |
| Bio databases IDs | |
| Aliases | cyclic nucleotide gated channel subunit alpha 2 |
| Synonyms | CNCA, CNCA1, Cncg4, Cng, CNG2, CNG channel 2, Cyclic nucleotide gated channel 2, cyclic nucleotide gated channel alpha 2, cyclic nucleotide gated channel subunit alpha 2, cyclic nucleotide gated channel subunit α 2, cyclic nucleotide gated channel α 2, LOC100911965, OCNC1, OCNCa, OCNCALPHA, OLFCH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNGA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclic nucleotide-binding domain
- C-terminal leucine zipper domain of cyclic nucleotide-gated channels
- Ion transport protein
- binding protein
- intracellular cGMP activated cation channel
- intracellular cAMP activated cation channel
- identical protein binding
- ion channel
- 3',5'-cGMP binding
- Cyclic nucleotide-monophosphate binding domain
- CAP_ED
Pathways
Biological processes and signaling networks where the CNGA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent-insoluble fractions
- cilia
- cell surface
- cellular membrane
- olfactory cilia
- Golgi membrane
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNGA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- sodium ion transport
- sensory perception of smell
- calcium ion transport
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- intracellular cyclic nucleotide activated cation channel complex
- Golgi-associated vesicle membrane
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- calcium channel activity
- intracellular cAMP activated cation channel activity
- cAMP binding
- intracellular cGMP activated cation channel activity
- cGMP binding