Tbcb Gene Summary [Mouse]
Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in cytosol. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbcb |
| Official Name | tubulin folding cofactor B [Source:MGI Symbol;Acc:MGI:1913661] |
| Ensembl ID | ENSMUSG00000006095 |
| Bio databases IDs | |
| Aliases | tubulin folding cofactor B |
| Synonyms | 2410007D12Rik, CG22, CKAP1, Ckap1 predicted, CKAPI, LOC100911774, LOC103690005, TCoB, TUBULIN FOLDING COFACTOR B, ZH14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbcb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubl1_cv_Nsp3_N-like
- CAP-Gly domain
- protein binding
- CAP_GLY
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbcb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tubulin complex assembly
- nervous system development
- cell differentiation
- post-chaperonin tubulin folding pathway
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- microtubule plus end
- cytoplasm
- cell cortex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule plus-end binding
- alpha-tubulin binding