Mgst1 Gene Summary [Mouse]
Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human MGST1 (microsomal glutathione S-transferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgst1 |
| Official Name | microsomal glutathione S-transferase 1 [Source:MGI Symbol;Acc:MGI:1913850] |
| Ensembl ID | ENSMUSG00000008540 |
| Bio databases IDs | |
| Aliases | microsomal glutathione S-transferase 1 |
| Synonyms | 1500002K10Rik, Glutathione s-transferase 1, Gst, GST12, MGST, MGST-I, microsomal glutathione S-transferase 1, MICROSOMAL GT, PMAN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mgst1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- glutathione transferase
- MAPEG family
- enzyme
- protein binding
- glutathione peroxidase
- identical protein binding
Pathways
Biological processes and signaling networks where the Mgst1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- asthma
- acute myeloid leukemia
- breast cancer
- exfoliative glaucoma
- esophageal adenocarcinoma
- idiopathic scoliosis
- metastatic colorectal cancer
- esophageal carcinoma formation
regulates
- glutathione
- xenobiotic
- MGST1
- cysteinyl-leukotriene
role in cell
- survival
- response by
- priming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apical compartment
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- mitochondrial outer membrane
- lysosome membrane
- peroxisome membrane
- interchromatin granule clusters
- peroxisomes
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mgst1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione transport
- cellular response to lipid hydroperoxide
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- peroxisomal membrane
- membrane
- mitochondrion
- endoplasmic reticulum
- mitochondrial outer membrane
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutathione peroxidase activity
- protein binding
- glutathione transferase activity