Abl2 Gene Summary [Mouse]
Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of establishment of T cell polarity; and synapse maturation. Acts upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; diaphragm; hemolymphoid system gland; hindlimb long bone; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abl2 |
| Official Name | v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) [Source:MGI Symbol;Acc:MGI:87860] |
| Ensembl ID | ENSMUSG00000026596 |
| Bio databases IDs | |
| Aliases | v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) |
| Synonyms | AA536808, ABLL, ABL proto-oncogene 2, non-receptor tyrosine kinase, ARG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- cytoskeleton binding domain
- protein-tyrosine kinase
- Protein kinase domain
- enzyme activator activity
- proline rich domain
- Sh3 domain binding motif
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
- microtubule binding domain
- Protein kinase (unclassified specificity)
- G-actin-binding domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- phosphotyrosine binding
- non-membrane spanning protein tyrosine kinase
- protein binding
- magnesium ion binding
- F-actin binding
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- actin filament binding
- kinase domain
- actin-binding domain
- F-actin binding domain
- Protein Kinases, catalytic domain
- actin monomer binding
- tyrosine kinase domain
- manganese ion binding
Pathways
Biological processes and signaling networks where the Abl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- leukemia
- cutaneous melanoma
- precursor B-cell acute lymphoblastic leukemia
- chronic myeloid leukemia
- obesity
- acute lymphoblastic lymphoma
- chronic phase chronic myeloid leukemia
- T acute lymphoblastic leukemia
- accelerated phase chronic myelogenous leukemia
role in cell
- quantity
- size
- cell viability
- phosphorylation in
- apoptosis
- expression in
- cell death
- proliferation
- loss
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- actin cytoskeleton
- cytosol
- apical cell surfaces
- dendritic spines
- synaptosomes
- cytoplasmic vesicles
- cellular protrusions
- lamellipodia
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- protein modification process
- exploration behavior
- negative regulation of Rho protein signal transduction
- signal transduction
- epidermal growth factor receptor signaling pathway
- cell adhesion
- protein phosphorylation
- elevation of cytosolic calcium ion concentration
- positive regulation of T cell migration
- regulation of actin cytoskeleton organization
- positive regulation of oxidoreductase activity
- cellular response to retinoic acid
- regulation of autophagy
- regulation of cell motility
- positive regulation of neuron projection development
- regulation of endocytosis
- regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- actin filament binding
- phosphotyrosine binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- manganese ion binding
- protein kinase activity
- actin monomer binding