Evi5 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; liver; maxillary process; and paravertebral ganglion. Orthologous to human EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Evi5 |
| Official Name | ecotropic viral integration site 5 [Source:MGI Symbol;Acc:MGI:104736] |
| Ensembl ID | ENSMUSG00000011831 |
| Bio databases IDs | |
| Aliases | ecotropic viral integration site 5 |
| Synonyms | ecotropic viral integration site 5, NB4S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Evi5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tropomyosin
- Mechanosensitive ion channel porin domain
- Rab-GTPase-TBC domain
- TPR/MLP1/MLP2-like protein
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
- Tektin family
- Intermediate filament protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- multiple sclerosis
- allergy
- schizophrenia
- systemic lupus erythematosus
- COVID-19
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- exhaustion
- eczema
role in cell
- cell viability
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Evi5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- retrograde transport, endosome to Golgi
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- small GTPase binding