Slc9a5 Gene Summary [Mouse]
Predicted to enable arrestin family protein binding activity; potassium:proton antiporter activity; and sodium:proton antiporter activity. Predicted to be involved in monoatomic cation transmembrane transport and regulation of intracellular pH. Predicted to be located in several cellular components, including focal adhesion; neuron spine; and recycling endosome membrane. Predicted to be active in plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc9a5 |
| Official Name | solute carrier family 9 (sodium/hydrogen exchanger), member 5 [Source:MGI Symbol;Acc:MGI:2685542] |
| Ensembl ID | ENSMUSG00000014786 |
| Bio databases IDs | |
| Aliases | solute carrier family 9 (sodium/hydrogen exchanger), member 5 |
| Synonyms | Gm696, NHE5, solute carrier family 9 member A5, solute carrier family 9 (sodium/hydrogen exchanger), member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc9a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium/hydrogen exchanger family
- sodium/hydrogen exchanger 3
- protein binding
- transporter
- sodium:hydrogen antiporter
Pathways
Biological processes and signaling networks where the Slc9a5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
role in cell
- autophagy in
- migration
- formation
- abnormal morphology
- phosphorylation in
- degradation in
- formation in
- aggregation in
- outgrowth in
- pH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular space
- perinuclear region
- cellular membrane
- focal adhesions
- endosomes
- endosomal membrane
- neurites
- synapse
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc9a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- regulation of intracellular pH
- potassium ion transmembrane transport
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- neuron spine
- focal adhesion
- postsynaptic membrane
- dendritic spine membrane
- membrane
- synapse
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- potassium:hydrogen antiporter activity
- sodium:hydrogen antiporter activity