Cd46 Gene Summary [Mouse]
Predicted to enable cadherin binding activity. Predicted to contribute to endopeptidase activity. Predicted to be involved in several processes, including positive regulation of T cell activation; regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to be located in basolateral plasma membrane; cell surface; and inner acrosomal membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in testis. Used to study age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd46 |
| Official Name | CD46 antigen, complement regulatory protein [Source:MGI Symbol;Acc:MGI:1203290] |
| Ensembl ID | ENSMUSG00000016493 |
| Bio databases IDs | |
| Aliases | CD46 antigen, complement regulatory protein |
| Synonyms | AHUS2, CD46 antigen, CD46 antigen, complement regulatory protein, CD46 molecule, MCP, Membrane cofactor, MIC10, TLX, TRA2.10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd46 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- ectodomain
- protein binding
- CCP
- endopeptidase
- cytoplasmic domain
- STP box
- cadherin binding
- Sushi repeat (SCR repeat)
- cytosolic tail domain
- transmembrane receptor
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Cd46 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- atypical hemolytic uremic syndrome
- thrombotic microangiopathy
- susceptibility to atypical hemolytic uremic syndrome type 2
- Alzheimer disease
- febrile seizure
- idiopathic pulmonary fibrosis
- gastric epithelial cancer
- major depression
- familial atypical hemolytic uremic syndrome
role in cell
- activation in
- proliferation
- expression in
- production in
- activation
- morphology
- migration
- attachment
- binding
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- pH resistant lipid raft fraction
- cell junction
- cell surface
- cellular membrane
- inner membrane
- basolateral membrane
- acrosome
- exosomes
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd46 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of complement activation, classical pathway
- viral entry into host cell
- sequestering of extracellular ligand from receptor
- regulation of Notch signaling pathway
- adaptive immune response
- positive regulation of T cell proliferation
- single fertilization
- positive regulation of regulatory T cell differentiation
- T cell mediated immunity
- negative regulation of gene expression
- positive regulation of memory T cell differentiation
- positive regulation of gene expression
- complement activation, classical pathway
- innate immune response
- positive regulation of interleukin-10 production
- positive regulation of transforming growth factor beta production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- inner acrosomal membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- signaling receptor activity
- viral receptor activity