Auts2

Predicted to enable chromatin binding activity. Involved in several processes, including generation of neurons; positive regulation of Rac protein signal transduction; and positive regulation of lamellipodium assembly. Acts upstream of or within innate vocalization behavior and righting reflex. Located in growth cone and nucleus. Colocalizes with actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 26. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 26. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Auts2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Auts2 gene, providing context for its role in the cell.