POLD2 Gene Summary [Human]
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | POLD2 |
| Official Name | DNA polymerase delta 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:9176] |
| Ensembl ID | ENSG00000106628 |
| Bio databases IDs | |
| Aliases | DNA polymerase delta 2, accessory subunit, Pol delta B subunit (p50), DNA polymerase delta subunit p50 |
| Synonyms | DNA polymerase delta 2, accessory subunit, DNA polymerase δ 2, accessory subunit, p50, po1D2, polymerase (DNA directed), delta 2, regulatory subunit, Polymerase (DNA directed), delta 2, regulatory subunit 50kDa, polymerase (DNA directed), δ 2, regulatory subunit, Polymerase (DNA directed), δ 2, regulatory subunit 50kDa |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA polymerase delta subunit OB-fold domain
- DNA-directed DNA polymerase
- DNA polymerase alpha/epsilon subunit B
- enzyme
- protein binding
- metallophosphatase superfamily, metallophosphatase domain
Pathways
Biological processes and signaling networks where the POLD2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleolar fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA strand elongation involved in DNA replication
- DNA replication
- DNA-dependent DNA replication
- DNA biosynthetic process
- error-prone translesion synthesis
Cellular Component
Where in the cell the gene product is active
- delta DNA polymerase complex
- nucleus
- zeta DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding