Zc3h14 Gene Summary [Mouse]
Enables poly(A) binding activity. Involved in spermatogenesis and spliceosome-depend formation of circular RNA. Located in nuclear speck. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 56. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zc3h14 |
| Official Name | zinc finger CCCH type containing 14 [Source:MGI Symbol;Acc:MGI:1919824] |
| Ensembl ID | ENSMUSG00000021012 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH type containing 14 |
| Synonyms | 1010001P15RIK, 1700016A15Rik, 2700069A02Rik, FLJ11806, MRT56, MSUT-2, Npuk68, NY-REN-37, SUT2, UKp68, ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14: ZC3H14, zinc finger CCCH-type containing 14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zc3h14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA-binding, Nab2-type zinc finger
- mRNA 3' UTR binding
- poly(A) binding protein
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mental retardation
- placenta accreta spectrum
- amyotrophic lateral sclerosis
- autosomal recessive mental retardation type 56
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- nucleoli
- nuclear speckles
- cellular protrusions
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zc3h14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA stability
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- dendrite cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- poly(A) RNA binding