Pde10a Gene Summary [Mouse]
Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cAMP/PKA signal transduction. Is active in glutamatergic synapse. Is expressed in alimentary system; cardiovascular system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in striatal degeneration 2. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde10a |
| Official Name | phosphodiesterase 10A [Source:MGI Symbol;Acc:MGI:1345143] |
| Ensembl ID | ENSMUSG00000023868 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 10A |
| Synonyms | ADSD2, cAMP/cGMP phosphodiesterase, HSPDE10A, IOLOD, LINC00473, LOC105369172, LOC105378114, PDE10A19, phosphodiesterase 10A, RP11 252P192 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde10a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- cyclic-nucleotide phosphodiesterase
- cGMP-stimulated cyclic-nucleotide phosphodiesterase
- GAF domain
- 3',5'-cAMP binding
- enzyme
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
- Domain present in phytochromes and cGMP-specific phosphodiesterases
Pathways
Biological processes and signaling networks where the Pde10a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic fibrosis
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- cardiovascular disorder
- heart failure
- coronary disease
- myocardial ischemia
- heart disease
- coronary artery disease
- COVID-19
role in cell
- proliferation
- migration
- expression in
- invasion by
- cellular infiltration by
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- insoluble fractions
- glutaminergic synapse
- perinuclear region
- membrane surface
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- synaptic vesicles
- nerve ending
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde10a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP catabolic process
- negative regulation of cGMP-mediated signaling
- cAMP catabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
- metal ion binding
- cAMP binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- cGMP binding
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity