Net1 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within myoblast migration. Predicted to be located in cytoplasm and nucleus. Is expressed in forelimb bud and submandibular gland primordium epithelium. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Net1 |
| Official Name | neuroepithelial cell transforming gene 1 [Source:MGI Symbol;Acc:MGI:1927138] |
| Ensembl ID | ENSMUSG00000021215 |
| Bio databases IDs | |
| Aliases | neuroepithelial cell transforming gene 1 |
| Synonyms | ARHGEF8, mNET1, neuroepithelial cell transforming 1, neuroepithelial cell transforming gene 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Net1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Rho-binding domain
- PDZ binding motif
- RhoGEF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- streptozotocin induced type1 diabetes
role in cell
- apoptosis
- activation in
- expression in
- growth
- number
- migration
- phosphorylation in
- cell cycle progression
- invasion by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- focal adhesions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Net1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- myoblast migration
- regulation of cell growth
- regulation of small GTPase mediated signal transduction
- signal transduction
- positive regulation of apoptotic process
- cellular response to ionizing radiation
- cellular response to hydrogen peroxide
- positive regulation of GTPase activity
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity